منابع مشابه
Altered Cardiac High-Energy Phosphate Metabolism in Heart Failure
Background. The purpose of this work was to further define the value of cardiac 3'P magnetic resonance (MR) spectroscopy for patients with coronary artery disease and dilated cardiomyopathy. Methods and Results. Blood-corrected and Tl-corrected 3`P MR spectra of anteroseptal myocardium were obtained at rest using image-selected in vivo spectroscopy localization, a selected volume of 85± 12 cm3,...
متن کاملExercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure
Objective(s): Exercise training is a well-known accelerator for the treatment of chronic heart failure (CHF). The current study aimed to investigate the restorative effects of aerobic interval training (AIT) intervention on myocardial energy metabolism in CHF rats. Materials and Methods: Post-myocardial infarction (MI) heart failure animal model was established. The Sprague-Dawley rats were ran...
متن کاملOptimization of Cardiac Metabolism in Heart Failure
The derangement of the cardiac energy substrate metabolism plays a key role in the pathogenesis of heart failure. The utilization of non-carbohydrate substrates, such as fatty acids, is the predominant metabolic pathway in the normal heart, because this provides the highest energy yield per molecule of substrate metabolized. In contrast, glucose becomes an important preferential substrate for m...
متن کاملEnergy metabolism in heart failure and remodelling.
Myocytes of the failing heart undergo impressive metabolic remodelling. The time line for changes in the pathways for ATP synthesis in compensated hypertrophy is: flux through the creatine kinase (CK) reaction falls as both creatine concentration ([Cr]) and CK activity fall; increases in [ADP] and [AMP] lead to increases in glucose uptake and utilization; fatty acid oxidation either remains the...
متن کاملANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism
A cardioprotective response that alters ventricular contractility or promotes cardiomyocyte enlargement occurs with increased workload in conditions such as hypertension. When that response is excessive, pathological cardiac remodelling occurs, which can progress to heart failure, a leading cause of death worldwide. Mechanisms underlying this response are not fully understood. Here, we report t...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2021
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.121.318241